Controlled Human Malaria Infection
نویسندگان
چکیده
منابع مشابه
Taking a Bite out of Malaria: Controlled Human Malaria Infection by Needle and Syringe
In this issue of AJTMH, Roestenberg and colleagues report that healthy adults can be infected by the intradermal injection of aseptic, purified, vialed, cryopreserved Plasmodium falciparum sporozoites (PfSPZ Challenge). Because of the potential of this “challenge in a bottle” to standardize and dramatically expand the use of controlled human malaria infections (CHMI) for assessment of malaria v...
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To understand the effect of previous malaria exposure on antiparasite immune responses is important for developing successful immunization strategies. Controlled human malaria infections (CHMIs) using cryopreserved Plasmodium falciparum sporozoites provide a unique opportunity to study differences in acquisition or recall of antimalaria immune responses in individuals from different transmissio...
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Controlled human malaria infection (CHMI) in healthy human volunteers is an important and powerful tool in clinical malaria vaccine development. However, power calculations are essential to obtain meaningful estimates of protective efficacy, while minimizing the risk of adverse events. To optimize power calculations for CHMI-based malaria vaccine trials, we developed a novel non-linear statisti...
متن کاملLaboratory diagnosis methods of malaria infection
Background and Aim: To manage and control malaria - one of the most important infectious diseases in tropical and subtropical regions – a quick and accurate malaria diagnosis method is necessary as a high priority. For this purpose, several methods have been developed for the diagnosis of malaria, and currently, the examining the peripheral blood slide with an optical microscope as a gold stand...
متن کاملLaboratory diagnostic methods of malaria infection
Malaria is one of the most important tropical infectious diseases. The incidence of malaria worldwide is estimated to be 300–500 million clinical cases each year with a mortality of between one and three million people worldwide annually. The accurate and timely diagnosis of malaria infection is essential if severe complications and mortality are to be reduced by early specific antimalarial tre...
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ژورنال
عنوان ژورنال: Journal of Infectious Diseases
سال: 2014
ISSN: 0022-1899,1537-6613
DOI: 10.1093/infdis/jiu063